PF3D7_1028200

Genome location: Pf3D7_10_v3:1,165,685..1,167,543(-)

Genome classification: Core

Function and Localization

Product Description: RING zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.03	0.98
Trophozoite	expressed	0.18	0.88
Schizont	expressed	0.14	0.90
Gametocyte	expressed	0.20	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1028200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.258 | MFS: -2.506 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0512300)

Relative Growth Rate: 0.07 ± 0.15
Confidence: 5.19

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJC2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121687

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	6	9	24
disruptive	7	12	7	26
missense	7	12	7	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	7	25	16	20
disruptive	12	25	16	47
missense	10	24	15	37

PlasmoDB Total SNPs: 132

Non-coding: 111 | Synonymous: 14 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 274 | Molecular Weight (kDa): 33.158

UniProt ID(s): Q8IJC2

PDB ID(s): None

Isoelectric Point: 7.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001841	Zinc finger, RING-type
PFam	PF13639	Zinc finger, RING-type
Superfamily	SSF57850	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094