Genome location: Pf3D7_10_v3:1,167,709..1,169,301(-)
Genome classification: Core
Product Description: rRNA-processing protein EBP2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Component | GO:0030687 | preribosome, large subunit precursor |
| Process | GO:0006364 | rRNA processing |
| Process | GO:0042273 | ribosomal large subunit biogenesis |
| Process | GO:0042254 | ribosome biogenesis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.81 | 0.63 |
| Trophozoite | expressed | 0.61 | 0.67 |
| Schizont | possibly expressed | 0.09 | 0.94 |
| Gametocyte | expressed | 0.61 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1028300
Resistome Missense Mutations: H169N
Resistome Compounds with Missense Mutations: MMV028038
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 3 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.564 | MFS: -2.62 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJC1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102606
Most Similar Human Ortholog: H7C2Q8
TM-align score: 0.50 | RMSD: 4.54
Seq Identity: 0.24 | Length: 193 / 315
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000117395 | EBNA1 binding protein 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 11 | 18 |
| disruptive | 9 | 40 | 33 | 49 |
| missense | 9 | 35 | 29 | 41 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 24 | 22 | 22 |
| disruptive | 35 | 105 | 46 | 93 |
| missense | 19 | 78 | 37 | 55 |
PlasmoDB Total SNPs: 128
Non-coding: 98 | Synonymous: 15 | Nonsynonymous: 15 | Stop Codon: 0
Protein Length: 315 | Molecular Weight (kDa): 37.727
UniProt ID(s): Q8IJC1
PDB ID(s): None
Isoelectric Point: 10.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008610 | Eukaryotic rRNA processing |
| PFam | PF05890 | Eukaryotic rRNA processing |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 37037443 | Serological Markers of Exposure to Plasmodium falciparum and Plasmodium vivaxInfection in Southwestern Ethiopia | Jeang B, Lee MC, ..., Dent A | 10.4269/ajtmh.22-0645 |
| 35714097 | Antibody response to a new member of the DBL family (EBP2) after a briefPlasmodium vivax exposure | Lima BAS, Fernandes GM, ..., Kano FS | 10.1371/journal.pntd.0010493 |
| 37918005 | Determination of Plasmodium vivax and Plasmodium falciparum Malaria Exposure inTwo Ethiopian Communities and Its Relationship to Duffy Expression | Bradley L, Yewhalaw D, ..., Dent A | 10.4269/ajtmh.22-0644 |
| 30761253 | C/EBPbeta and YY1 bind and interact with Smad3 to modulatelipopolysaccharide-induced amelotin gene transcription in mouse gingivalepithelial cells | Nakayama Y, Kobayashi R, ..., Ogata Y | 10.1002/2211-5463.12566 |