Product Description: ribosome biogenesis protein RPF2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005730 | nucleolus |
| Component | GO:0005634 | nucleus |
| Function | GO:0019843 | rRNA binding |
| Process | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0000027 | ribosomal large subunit assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.35 | 0.82 |
| Trophozoite | expressed | 0.27 | 0.84 |
| Schizont | possibly expressed | 0.06 | 0.96 |
| Gametocyte | possibly expressed | 0.24 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1028400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.167 | MFS: -2.764 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJC0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102220
Most Similar Human Ortholog: Q5VXN0
TM-align score: 0.92 | RMSD: 2.00
Seq Identity: 0.21 | Length: 214 / 483
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000197498 | ribosome production factor 2 homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 18 | 13 | 25 |
| disruptive | 12 | 38 | 22 | 71 |
| missense | 11 | 34 | 20 | 61 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 49 | 23 | 33 |
| disruptive | 20 | 103 | 45 | 121 |
| missense | 17 | 83 | 39 | 76 |
PlasmoDB Total SNPs: 164
Non-coding: 68 | Synonymous: 56 | Nonsynonymous: 39 | Stop Codon: 1
Protein Length: 483 | Molecular Weight (kDa): 57.057
UniProt ID(s): Q8IJC0
PDB ID(s): None
Isoelectric Point: 5.18
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007109 | Brix domain |
| InterPro | IPR039770 | Ribosome biogenesis protein Rpf2 |
| PFam | PF04427 | Brix domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |