About Gene List

PF3D7_1028500

Genome location: Pf3D7_10_v3:1,171,988..1,175,373(-)

Genome classification: Core

Function and Localization

Product Description: partial CSTF domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 1.03 0.53
Trophozoite not expressed 0.83 0.55
Schizont not expressed 0.37 0.77
Gametocyte expressed 1.07 0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1028500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.987 | MFS: -2.54 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJB9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532306

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 30 29 51
disruptive 75 156 90 163
missense 29 111 66 115

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 15 75 36 54
disruptive 131 325 146 274
missense 55 231 108 153

PlasmoDB Total SNPs: 237

Non-coding: 56 | Synonymous: 86 | Nonsynonymous: 95 | Stop Codon: 0

Protein Information

Protein Length: 838 | Molecular Weight (kDa): 98.543

UniProt ID(s): Q8IJB9

PDB ID(s): None

Isoelectric Point: 5.11

Protein Domain Annotations:

Source Family ID Description
InterPro IPR031721 Partial cleavage stimulation factor domain
InterPro IPR035979 RNA-binding domain superfamily
PFam PF15861 Partial cleavage stimulation factor domain
Superfamily SSF54928 RNA-binding domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108