About Gene List

PF3D7_1028600

Genome location: Pf3D7_10_v3:1,176,028..1,177,887(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.99
Trophozoite not expressed 0.15 0.90
Schizont not expressed 0.18 0.88
Gametocyte not expressed 0.23 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1028600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.204 | MFS: -2.708 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0512700)

  • Relative Growth Rate: 0.91 ± 0.08
  • Confidence: 6.43

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0512700)

Modification: Disrupted | RMgm-1992

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJB8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533102

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 9 4 7
disruptive 0 13 13 24
missense 0 13 11 18

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 1 20 6 7
disruptive 3 41 16 63
missense 3 34 14 46

PlasmoDB Total SNPs: 155

Non-coding: 150 | Synonymous: 1 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 171 | Molecular Weight (kDa): 19.555

UniProt ID(s): Q8IJB8

PDB ID(s): None

Isoelectric Point: 4.73

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
27714937 PlasmoSEP: Predicting surface-exposed proteins on the malaria parasite usingsemisupervised self-training and expert-annotated data. El-Manzalawy Y, Munoz EE, Lindner SE, Honavar V 10.1002/pmic.201600249