Genome location: Pf3D7_10_v3:1,184,559..1,186,461(-)
Genome classification: Core
Product Description: inner membrane complex protein 1m, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0070258 | inner membrane pellicle complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.01 | 0.99 |
| Schizont | expressed | 0.42 | 0.82 |
| Gametocyte | expressed | 0.33 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1028900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.758 | MFS: -2.189 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0513000)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0514100)
Modification: Tagged | RMgm-4497
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJB5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_111692
Most Similar Human Ortholog: C9J5X9
TM-align score: 0.23 | RMSD: 7.07
Seq Identity: 0.07 | Length: 150 / 369
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000181544 | FA complementation group B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 16 | 9 | 20 |
| disruptive | 6 | 41 | 21 | 65 |
| missense | 6 | 40 | 19 | 58 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 32 | 15 | 31 |
| disruptive | 20 | 93 | 39 | 118 |
| missense | 14 | 85 | 36 | 88 |
PlasmoDB Total SNPs: 97
Non-coding: 75 | Synonymous: 16 | Nonsynonymous: 5 | Stop Codon: 1
Protein Length: 369 | Molecular Weight (kDa): 43.843
UniProt ID(s): Q8IJB5
PDB ID(s): None
Isoelectric Point: 8.16
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25475193 | Plasmodium alveolins possess distinct but structurally and functionally relatedmulti-repeat domains. | Al-Khattaf FS, Tremp AZ, Dessens JT | 10.1007/s00436-014-4226-9 |
| 27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |