PF3D7_1029100

Genome location: Pf3D7_10_v3:1,189,990..1,195,098(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	possibly expressed	nd	nd
Gametocyte	not expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1029100.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.129 | MFS: -3.073 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A143ZYR7

"Best" AlphaFill ligand hit: UDP (uridine-5'-diphosphate, Local RMSD=0.61) with 6H4M (Global RMSD=19.53)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533023

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	45	31	80
disruptive	42	163	89	234
missense	32	144	83	208

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	98	59	101
disruptive	81	329	177	343
missense	53	278	152	265

PlasmoDB Total SNPs: 156

Non-coding: 52 | Synonymous: 65 | Nonsynonymous: 39 | Stop Codon: 0

Protein Information

Protein Length: 1396 | Molecular Weight (kDa): 168.497

UniProt ID(s): Q8IJB4

PDB ID(s): None

Isoelectric Point: 9.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A