PF3D7_1029200

Genome location: Pf3D7_10_v3:1,195,142..1,197,783(+)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.58	0.73
Trophozoite	expressed	0.29	0.84
Schizont	expressed	0.06	0.96
Gametocyte	expressed	0.57	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1029200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.143 | MFS: -2.861 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJB3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533209

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	27	17	45
disruptive	8	55	46	106
missense	4	47	44	96

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	10	52	22	47
disruptive	24	137	89	160
missense	13	113	68	117

PlasmoDB Total SNPs: 49

Non-coding: 20 | Synonymous: 18 | Nonsynonymous: 10 | Stop Codon: 1

Protein Information

Protein Length: 555 | Molecular Weight (kDa): 65.779

UniProt ID(s): Q8IJB3

PDB ID(s): None

Isoelectric Point: 4.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily