PF3D7_1029300

Genome location: Pf3D7_10_v3:1,197,379..1,200,268(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.14	0.93
Trophozoite	expressed	0.63	0.67
Schizont	expressed	0.09	0.94
Gametocyte	expressed	0.56	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1029300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.174 | MFS: -2.635 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJB2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145157

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	36	21	45
disruptive	64	157	71	147
missense	33	112	55	123

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	70	31	63
disruptive	102	259	100	199
missense	52	189	83	152

PlasmoDB Total SNPs: 176

Non-coding: 79 | Synonymous: 44 | Nonsynonymous: 51 | Stop Codon: 2

Protein Information

Protein Length: 735 | Molecular Weight (kDa): 87.542

UniProt ID(s): Q8IJB2

PDB ID(s): None

Isoelectric Point: 9.3

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A