Genome location: Pf3D7_10_v3:1,200,735..1,203,235(-)
Genome classification: Core
Product Description: cell division control protein CDC50C
SignalP Peptide: N/A
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.31 | 0.85 |
| Trophozoite | expressed | 0.62 | 0.65 |
| Schizont | expressed | 0.40 | 0.73 |
| Gametocyte | expressed | 0.63 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1029400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.141 | MFS: -2.582 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0514500)
Modification: Tagged | RMgm-5054
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJB1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 19 | 20 | 22 |
| disruptive | 8 | 22 | 17 | 34 |
| missense | 8 | 19 | 15 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 38 | 22 | 33 |
| disruptive | 20 | 57 | 31 | 72 |
| missense | 11 | 40 | 30 | 57 |
PlasmoDB Total SNPs: 117
Non-coding: 92 | Synonymous: 16 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 501 | Molecular Weight (kDa): 59.438
UniProt ID(s): Q8IJB1
PDB ID(s): None
Isoelectric Point: 9.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005045 | CDC50/LEM3 family |
| PFam | PF03381 | CDC50/LEM3 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 35862778 | CDC50 Orthologues in Plasmodium falciparum Have Distinct Roles in MerozoiteEgress and Trophozoite Maturation. | Patel A, Nofal SD, Blackman MJ, Baker DA | 10.1128/mbio.01635-22 |
| 33307135 | Generation of Plasmodium yoelii malaria parasite for conditional degradation ofproteins | Liu C, Yang Z, ..., Yuan J | 10.1016/j.molbiopara.2020.111346 |
| 34301597 | A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetesfor mosquito transmission | Yang Z, Shi Y, ..., Yuan J | 10.1126/sciadv.abf6015 |