Genome location: Pf3D7_10_v3:1,211,524..1,213,888(-)
Genome classification: Core
Product Description: heptatricopeptide repeat and RAP domain-containing protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.23 | 0.85 |
| Schizont | expressed | 0.17 | 0.88 |
| Gametocyte | possibly expressed | 0.14 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1029800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.952 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0513800)
Modification: Tagged | RMgm-4467
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJA7
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 12 | 25 |
| disruptive | 2 | 27 | 15 | 39 |
| missense | 2 | 27 | 15 | 36 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 40 | 24 | 39 |
| disruptive | 7 | 54 | 36 | 117 |
| missense | 7 | 47 | 29 | 78 |
PlasmoDB Total SNPs: 120
Non-coding: 105 | Synonymous: 4 | Nonsynonymous: 11 | Stop Codon: 0
Protein Length: 437 | Molecular Weight (kDa): 52.4
UniProt ID(s): Q8IJA7
PDB ID(s): None
Isoelectric Point: 10.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR013584 | RAP domain |
| PFam | PF08373 | RAP domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30102371 | Identification of clustered organellar short (cos) RNAs and of a conserved familyof organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in themalaria parasite. | Hillebrand A, Matz JM, ..., Schmitz-Linneweber C | 10.1093/nar/gky710 |
| 32764806 | Malaria preventive practices and delivery outcomes: A cross-sectional study ofparturient women in a tertiary hospital in Eastern Uganda | Nekaka R, Nteziyaremye J, ..., Wandabwa J | 10.1371/journal.pone.0237407 |
| 26190461 | Anti-Plasmodium falciparum activity of quinoline-sulfonamide hybrids | Pinheiro LC, Boechat N, ..., Krettli AU | 10.1016/j.bmc.2015.06.056 |
| 23805492 | [Evaluation of the efficiency of rapid tests in identifying malaria patients andparasite carriers in the Republic of Tajikistan] | Karimov SS, Saiburkhonov DS | https://pubmed.ncbi.nlm.nih.gov/23805492/ |