About Gene List

PF3D7_1029900

Genome location: Pf3D7_10_v3:1,216,830..1,222,661(+)

Genome classification: Core

Function and Localization

Product Description: ORC3 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite expressed 0.56 0.73
Schizont expressed 2.02 0.34
Gametocyte expressed 1.03 0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1029900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.826 | #Insertions: 4

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0513900)

  • Relative Growth Rate: 0.71 ± 0.14
  • Confidence: 5.31

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0513900)

Modification: Disrupted | RMgm-1997

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJA6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533647

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 29 99 55 108
disruptive 62 199 129 297
missense 25 161 113 257

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 42 202 73 105
disruptive 109 478 232 456
missense 48 375 179 279

PlasmoDB Total SNPs: 297

Non-coding: 90 | Synonymous: 170 | Nonsynonymous: 37 | Stop Codon: 0

Protein Information

Protein Length: 1697 | Molecular Weight (kDa): 201.369

UniProt ID(s): Q8IJA6

PDB ID(s): None

Isoelectric Point: 8.46

Protein Domain Annotations:

Source Family ID Description
InterPro IPR020795 Origin recognition complex, subunit 3
PFam PF07034 Origin recognition complex, subunit 3
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104