Genome location: Pf3D7_10_v3:1,229,987..1,233,020(-)
Genome classification: Core
Product Description: claudin-like apicomplexan microneme protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 4
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0020009 | microneme |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.14 | 0.92 |
| Trophozoite | expressed | 0.03 | 0.98 |
| Schizont | expressed | 0.59 | 0.71 |
| Gametocyte | expressed | 0.18 | 0.89 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1030200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.993 | MFS: -1.904 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0514200)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0514200)
Modification: Mutated | RMgm-5253
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJA3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 28 | 13 | 29 |
| disruptive | 23 | 51 | 26 | 57 |
| missense | 7 | 34 | 16 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 60 | 19 | 27 |
| disruptive | 36 | 103 | 45 | 138 |
| missense | 14 | 68 | 30 | 79 |
PlasmoDB Total SNPs: 250
Non-coding: 172 | Synonymous: 50 | Nonsynonymous: 28 | Stop Codon: 0
Protein Length: 450 | Molecular Weight (kDa): 51.392
UniProt ID(s): Q8IJA3
PDB ID(s): None
Isoelectric Point: 9.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 27594426 | A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential ApicomplexanGenes. | Sidik SM, Huet D, ..., Lourido S | 10.1016/j.cell.2016.08.019 |
| 38431723 | Comparison of blood loss between intra-articular microporous polysaccharidehemospheres powder and tranexamic acid following primary total knee arthroplasty | Jeon YD, Cha JR, ..., Park KB | 10.1038/s41598-024-55871-3 |