About Gene List

PF3D7_1030300

Genome location: Pf3D7_10_v3:1,233,044..1,238,180(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 2.07 0.26
Trophozoite not expressed 0.92 0.54
Schizont expressed 1.34 0.35
Gametocyte expressed 1.18 0.43

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1030300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.494 | MFS: -2.461 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJA2

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=2.55) with 6JWQ (Global RMSD=5.93)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533361

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 72 29 76
disruptive 52 185 78 213
missense 37 153 62 173

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 135 35 96
disruptive 96 388 147 370
missense 59 291 109 245

PlasmoDB Total SNPs: 271

Non-coding: 155 | Synonymous: 63 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 1111 | Molecular Weight (kDa): 131.165

UniProt ID(s): Q8IJA2

PDB ID(s): None

Isoelectric Point: 9.48

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104