About Gene List

PF3D7_1030400

Genome location: Pf3D7_10_v3:1,241,767..1,242,977(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.96
Trophozoite not expressed 0.16 0.91
Schizont not expressed 0.25 0.85
Gametocyte not expressed 0.11 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1030400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.726 | #Insertions: 2

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0514400)

  • Relative Growth Rate: 1.08 ± 0.18
  • Confidence: 4.86

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0514400)

Modification: Disrupted | RMgm-2001

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJA1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_145664

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 11 8 13
disruptive 19 49 20 50
missense 13 34 10 33

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 24 15 18
disruptive 42 101 49 91
missense 24 63 31 51

PlasmoDB Total SNPs: 119

Non-coding: 71 | Synonymous: 28 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 278 | Molecular Weight (kDa): 33.356

UniProt ID(s): Q8IJA1

PDB ID(s): None

Isoelectric Point: 7.07

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097