PF3D7_1030800

Genome location: Pf3D7_10_v3:1,249,480..1,250,925(+)

Genome classification: Core

Function and Localization

Product Description: calmodulin, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0005509	calcium ion binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	not expressed	0.21	0.88
Schizont	possibly expressed	1.01	0.47
Gametocyte	possibly expressed	0.72	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1030800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.343 | MFS: -3.035 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ97

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139425

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	6	7	20
disruptive	2	21	12	30
missense	2	21	11	28

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	18	11	21
disruptive	7	53	26	47
missense	5	46	20	39

PlasmoDB Total SNPs: 108

Non-coding: 86 | Synonymous: 15 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 212 | Molecular Weight (kDa): 25.411

UniProt ID(s): Q8IJ97

PDB ID(s): None

Isoelectric Point: 5.26

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand domain pair
InterPro	IPR018247	EF-Hand 1, calcium-binding site
PFam	N/A	N/A
Superfamily	SSF47473	EF-hand domain pair