PF3D7_1031100

Genome location: Pf3D7_10_v3:1,254,553..1,256,102(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.23	0.85
Schizont	not expressed	0.17	0.89
Gametocyte	not expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1031100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.31 | MFS: -3.299 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0515100)

Relative Growth Rate: 0.11 ± 0.08
Confidence: 6.43

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ95

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532613

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	4	7	9
disruptive	7	27	27	41
missense	7	27	27	39

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	17	6	16
disruptive	16	65	33	48
missense	14	58	32	43

PlasmoDB Total SNPs: 133

Non-coding: 120 | Synonymous: 11 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 184 | Molecular Weight (kDa): 22.143

UniProt ID(s): Q8IJ95

PDB ID(s): None

Isoelectric Point: 9.04

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A