PF3D7_1031300

Genome location: Pf3D7_10_v3:1,259,098..1,263,892(+)

Genome classification: Core

Function and Localization

Product Description: SAE2 domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.14	0.93
Trophozoite	expressed	0.48	0.73
Schizont	expressed	0.35	0.79
Gametocyte	possibly expressed	0.51	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1031300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.706 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0515300)

Modification: Disrupted | RMgm-2007

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ92

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_110181

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	18	34	21	44
disruptive	62	155	79	189
missense	34	99	59	145

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	76	25	49
disruptive	113	362	119	270
missense	56	231	84	165

PlasmoDB Total SNPs: 536

Non-coding: 260 | Synonymous: 142 | Nonsynonymous: 134 | Stop Codon: 0

Protein Information

Protein Length: 919 | Molecular Weight (kDa): 109.277

UniProt ID(s): Q8IJ92

PDB ID(s): None

Isoelectric Point: 8.87

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013882	DNA endonuclease Ctp1, C-terminal
PFam	PF08573	DNA endonuclease Ctp1, C-terminal
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108