Genome location: Pf3D7_10_v3:1,263,906..1,269,524(+)
Genome classification: Core
Product Description: OTU-like cysteine protease
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.4.22.- (Cysteine endopeptidases.)
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0020011 | apicoplast |
Component | GO:0005829 | cytosol |
Component | GO:0031982 | vesicle |
Function | GO:0008233 | peptidase activity |
Function | GO:0004843 | thiol-dependent deubiquitinase |
Process | GO:1903060 | negative regulation of protein lipidation |
Process | GO:0016579 | protein deubiquitination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | possibly expressed | nd | nd |
Trophozoite | possibly expressed | nd | nd |
Schizont | expressed | nd | nd |
Gametocyte | expressed | nd | nd |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1031400.2
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.676 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0515350)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0515350)
Modification: Disrupted | RMgm-2008
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A039
"Best" AlphaFill ligand hit: 3CN (3-aminopropane, Local RMSD=0.76) with 4HXD (Global RMSD=7.61)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104209
Most Similar Human Ortholog: Q5T2D3
TM-align score: 0.40 | RMSD: 4.63
Seq Identity: 0.20 | Length: 190 / 938
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000169914 | OTU deubiquitinase 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 9 | 53 | 37 | 56 |
disruptive | 29 | 114 | 75 | 173 |
missense | 26 | 99 | 65 | 131 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 16 | 116 | 44 | 64 |
disruptive | 56 | 295 | 137 | 287 |
missense | 42 | 224 | 108 | 170 |
PlasmoDB Total SNPs: 273
Non-coding: 166 | Synonymous: 57 | Nonsynonymous: 50 | Stop Codon: 0
Protein Length: 938 | Molecular Weight (kDa): 111.71
UniProt ID(s): A0A143ZXT6
PDB ID(s): None
Isoelectric Point: 8.6
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR003323 | OTU domain |
InterPro | IPR038765 | Papain-like cysteine peptidase superfamily |
PFam | PF02338 | OTU domain |
Superfamily | SSF54001 | Papain-like cysteine peptidase superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |