Genome location: Pf3D7_10_v3:1,274,939..1,280,545(+)
Genome classification: Core
Product Description: protein GEXP15
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005682 | U5 snRNP |
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Function | GO:0019888 | protein phosphatase regulator activity |
| Function | GO:0043022 | ribosome binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.38 | 0.82 |
| Trophozoite | expressed | 0.93 | 0.51 |
| Schizont | expressed | 0.37 | 0.77 |
| Gametocyte | expressed | 0.65 | 0.65 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1031600
Resistome Missense Mutations: A567V, S573A
Resistome Compounds with Missense Mutations: Atovaquone, Proguanil
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.151 | MFS: -2.767 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0515400)
Modification: Tagged | RMgm-4653
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ89
"Best" AlphaFill ligand hit: ZZ7 ((2r,4s)-2-[(r)-{[(2r)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Local RMSD=1.70) with 7RCW (Global RMSD=30.98)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 35 | 18 | 57 |
| disruptive | 76 | 163 | 102 | 180 |
| missense | 41 | 104 | 76 | 129 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 79 | 30 | 61 |
| disruptive | 118 | 350 | 135 | 297 |
| missense | 60 | 237 | 95 | 144 |
PlasmoDB Total SNPs: 361
Non-coding: 213 | Synonymous: 77 | Nonsynonymous: 71 | Stop Codon: 0
Protein Length: 904 | Molecular Weight (kDa): 106.689
UniProt ID(s): Q8IJ89
PDB ID(s): None
Isoelectric Point: 4.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR035445 | GYF-like domain superfamily |
| InterPro | IPR039905 | CD2 antigen cytoplasmic tail-binding protein 2/Lin1 |
| PFam | N/A | N/A |
| Superfamily | SSF55277 | GYF-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 26988354 | Analysis of the interactome of the Ser/Thr Protein Phosphatase type 1 inPlasmodium falciparum. | Hollin T, De Witte C, ..., Khalife J | 10.1186/s12864-016-2571-z |
| 31348803 | Essential role of GEXP15, a specific Protein Phosphatase type 1 partner, inPlasmodium berghei in asexual erythrocytic proliferation and transmission. | Hollin T, De Witte C, ..., Khalife J | 10.1371/journal.ppat.1007973 |
| 37628837 | Characterization of GEXP15 as a Potential Regulator of Protein Phosphatase 1 inPlasmodium falciparum | Mansour H, Cabezas-Cruz A, ..., Khalife J | 10.3390/ijms241612647 |