Product Description: protein phosphatase inhibitor 3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0005515 | protein binding |
| Function | GO:0008157 | protein phosphatase 1 binding |
| Function | GO:0004864 | protein phosphatase inhibitor activity |
| Function | GO:0004865 | protein serine/threonine phosphatase inhibitor activity |
| Process | GO:0032515 | negative regulation of phosphoprotein phosphatase activity |
| Process | GO:0035308 | negative regulation of protein dephosphorylation |
| Process | GO:0006470 | protein dephosphorylation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.09 | 0.95 |
| Trophozoite | expressed | 0.15 | 0.90 |
| Schizont | expressed | 0.12 | 0.91 |
| Gametocyte | expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1031700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.996 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ88
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104011
Most Similar Human Ortholog: O60927
TM-align score: 0.26 | RMSD: 4.38
Seq Identity: 0.23 | Length: 52 / 116
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000204619 | protein phosphatase 1 regulatory inhibitor subunit 11 |
| ENSG00000206501 | protein phosphatase 1 regulatory inhibitor subunit 11 |
| ENSG00000227720 | protein phosphatase 1 regulatory inhibitor subunit 11 |
| ENSG00000233314 | protein phosphatase 1 regulatory inhibitor subunit 11 |
| ENSG00000234058 | protein phosphatase 1 regulatory inhibitor subunit 11 |
| ENSG00000236560 | protein phosphatase 1 regulatory inhibitor subunit 11 |
| ENSG00000237403 | protein phosphatase 1 regulatory inhibitor subunit 11 |
| ENSG00000237829 | protein phosphatase 1 regulatory inhibitor subunit 11 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 7 | 3 | 6 |
| disruptive | 1 | 8 | 9 | 22 |
| missense | 1 | 8 | 9 | 20 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 17 | 4 | 12 |
| disruptive | 2 | 25 | 25 | 41 |
| missense | 2 | 19 | 24 | 27 |
PlasmoDB Total SNPs: 161
Non-coding: 158 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 116 | Molecular Weight (kDa): 13.131
UniProt ID(s): Q8IJ88
PDB ID(s): None
Isoelectric Point: 4.95
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011107 | Type 1 protein phosphatase inhibitor |
| PFam | PF07491 | Type 1 protein phosphatase inhibitor |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 22128182 | Plasmodium falciparum inhibitor-3 homolog increases protein phosphatase type 1activity and is essential for parasitic survival. | Freville A, Landrieu I, ..., Khalife J | 10.1074/jbc.M111.276865 |