PF3D7_1031800

Genome location: Pf3D7_10_v3:1,282,058..1,284,276(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.37	0.78
Schizont	expressed	0.62	0.64
Gametocyte	expressed	0.21	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1031800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.966 | MFS: -2.634 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0515600)

Relative Growth Rate: 0.88 ± 0.12
Confidence: 5.60

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0515600)

Modification: Disrupted | RMgm-2009

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ87

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134647

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	29	22	24
disruptive	7	40	20	68
missense	7	40	19	61

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	49	32	28
disruptive	13	94	46	130
missense	9	82	42	77

PlasmoDB Total SNPs: 109

Non-coding: 86 | Synonymous: 15 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 425 | Molecular Weight (kDa): 50.812

UniProt ID(s): Q8IJ87

PDB ID(s): None

Isoelectric Point: 7.98

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A