PF3D7_1031900

Genome location: Pf3D7_10_v3:1,284,588..1,287,287(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MSIGHFIFILLILCILNVRDIKT

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.11	0.93
Schizont	possibly expressed	0.08	0.95
Gametocyte	expressed	0.37	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1031900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.329 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3D9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532389

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	25	21	44
disruptive	18	39	17	51
missense	18	38	17	47

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	59	34	51
disruptive	26	70	43	84
missense	25	59	38	57

PlasmoDB Total SNPs: 194

Non-coding: 150 | Synonymous: 24 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 600 | Molecular Weight (kDa): 71.554

UniProt ID(s): C6S3D9

PDB ID(s): None

Isoelectric Point: 7.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A