Genome location: Pf3D7_10_v3:1,287,320..1,290,508(-)
Genome classification: Core
Product Description: ribosome maturation factor RimM, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.58 | 0.67 |
| Schizont | possibly expressed | 0.14 | 0.91 |
| Gametocyte | expressed | 0.82 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1032000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.158 | MFS: -2.8 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ86
"Best" AlphaFill ligand hit: JFQ (trans-n-(3-aminopropyl)cyclohexane-1,4-diamine, Local RMSD=0.61) with 6I1N (Global RMSD=26.36)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 41 | 26 | 33 |
| disruptive | 24 | 87 | 41 | 136 |
| missense | 19 | 79 | 35 | 111 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 79 | 29 | 51 |
| disruptive | 50 | 191 | 85 | 186 |
| missense | 37 | 148 | 68 | 132 |
PlasmoDB Total SNPs: 176
Non-coding: 103 | Synonymous: 42 | Nonsynonymous: 31 | Stop Codon: 0
Protein Length: 736 | Molecular Weight (kDa): 86.571
UniProt ID(s): Q8IJ86
PDB ID(s): None
Isoelectric Point: 9.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002676 | RimM, N-terminal |
| InterPro | IPR009000 | Translation protein, beta-barrel domain superfamily |
| InterPro | IPR013087 | Zinc finger C2H2-type |
| PFam | PF01782 | RimM, N-terminal |
| Superfamily | SSF50447 | Translation protein, beta-barrel domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |