Genome location: Pf3D7_10_v3:1,292,394..1,298,406(+)
Genome classification: Core
Product Description: mRNA-decapping enzyme subunit 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000932 | P-body |
| Component | GO:0005634 | nucleus |
| Function | GO:0030234 | enzyme regulator activity |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0000290 | deadenylation-dependent decapping of nuclear-transcribed mRNA |
| Process | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.52 | 0.37 |
| Trophozoite | expressed | 0.97 | 0.49 |
| Schizont | expressed | 0.55 | 0.68 |
| Gametocyte | expressed | 1.16 | 0.42 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1032100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.17 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ85
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_113598
Most Similar Human Ortholog: A0A087WXD0
TM-align score: 0.92 | RMSD: 1.63
Seq Identity: 0.24 | Length: 102 / 1190
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000272886 | decapping mRNA 1A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 80 | 45 | 86 |
| disruptive | 84 | 210 | 123 | 247 |
| missense | 56 | 174 | 103 | 211 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 43 | 166 | 60 | 81 |
| disruptive | 150 | 467 | 186 | 453 |
| missense | 94 | 383 | 141 | 269 |
PlasmoDB Total SNPs: 443
Non-coding: 212 | Synonymous: 132 | Nonsynonymous: 99 | Stop Codon: 0
Protein Length: 1190 | Molecular Weight (kDa): 137.986
PDB ID(s): None
Isoelectric Point: 7.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010334 | mRNA-decapping enzyme subunit 1 |
| PFam | PF06058 | mRNA-decapping enzyme subunit 1 |
| Superfamily | SSF50729 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 37652331 | Isolation and characterization of a nephroprotective polysaccharide fromDendrobium chrysotoxum Lindl against LPS-induced acute kidney injury mice | Hao Y, Lao S, ..., Liao W | 10.1016/j.ijbiomac.2023.126614 |