About Gene List

PF3D7_1032300

Genome location: Pf3D7_10_v3:1,299,692..1,302,667(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005739 mitochondrion

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.18 0.91
Trophozoite expressed 0.47 0.75
Schizont possibly expressed 0.08 0.95
Gametocyte expressed 0.47 0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1032300

Resistome Missense Mutations: E68K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.119 | MFS: -2.997 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ84

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533554

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 47 29 64
disruptive 30 96 64 142
missense 22 90 57 124

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 96 46 52
disruptive 58 237 99 229
missense 36 199 85 164

PlasmoDB Total SNPs: 63

Non-coding: 3 | Synonymous: 33 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 871 | Molecular Weight (kDa): 106.543

UniProt ID(s): Q8IJ84

PDB ID(s): None

Isoelectric Point: 8.92

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21