Genome location: Pf3D7_10_v3:1,305,485..1,308,052(-)
Genome classification: Core
Product Description: DER1-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000839 | Hrd1p ubiquitin ligase ERAD-L complex |
| Component | GO:0030176 | integral component of endoplasmic reticulum membrane |
| Function | GO:0051787 | misfolded protein binding |
| Function | GO:1990381 | ubiquitin-specific protease binding |
| Process | GO:0030968 | endoplasmic reticulum unfolded protein response |
| Process | GO:0030433 | ubiquitin-dependent ERAD pathway |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.04 | 0.98 |
| Trophozoite | expressed | 0.15 | 0.90 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1032500
Resistome Missense Mutations: G5S
Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.592 | MFS: -2.35 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0516300)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0516300)
Modification: Disrupted | RMgm-2011
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ82
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 24 | 11 | 15 |
| disruptive | 1 | 5 | 6 | 14 |
| missense | 1 | 5 | 6 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 46 | 6 | 23 |
| disruptive | 2 | 16 | 21 | 57 |
| missense | 2 | 13 | 17 | 35 |
PlasmoDB Total SNPs: 178
Non-coding: 163 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 263 | Molecular Weight (kDa): 30.995
UniProt ID(s): Q8IJ82
PDB ID(s): None
Isoelectric Point: 9.88
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007599 | Derlin |
| PFam | PF04511 | Derlin |
| Superfamily | SSF144091 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 8631297 | Der1, a novel protein specifically required for endoplasmic reticulum degradationin yeast | Knop M, Finger A, ..., Wolf DH | https://pubmed.ncbi.nlm.nih.gov/8631297/ |