PF3D7_1032600

Genome location: Pf3D7_10_v3:1,308,244..1,310,077(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	expressed	0.18	0.88
Schizont	possibly expressed	0.07	0.95
Gametocyte	expressed	0.30	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1032600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.992 | MFS: -2.219 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ81

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_142216

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	15	3	16
disruptive	15	36	17	29
missense	15	36	16	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	22	6	24
disruptive	28	70	17	41
missense	24	62	15	29

PlasmoDB Total SNPs: 74

Non-coding: 53 | Synonymous: 8 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 350 | Molecular Weight (kDa): 41.759

UniProt ID(s): Q8IJ81

PDB ID(s): None

Isoelectric Point: 9.51

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003734	Domain of unknown function DUF155
PFam	PF02582	Domain of unknown function DUF155
Superfamily	N/A	N/A