About Gene List

PF3D7_1032700

Genome location: Pf3D7_10_v3:1,310,085..1,313,049(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Component GO:0005667 transcription regulator complex
Component GO:0031982 vesicle

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.36 0.83
Trophozoite expressed 0.62 0.65
Schizont expressed 0.41 0.74
Gametocyte not expressed 0.79 0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1032700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.423 | MFS: -3.485 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ80

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_132502

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 13 13 22
disruptive 27 69 37 71
missense 17 49 31 62

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 34 15 25
disruptive 41 131 46 104
missense 26 99 35 75

PlasmoDB Total SNPs: 290

Non-coding: 100 | Synonymous: 95 | Nonsynonymous: 94 | Stop Codon: 1

Protein Information

Protein Length: 553 | Molecular Weight (kDa): 65.543

UniProt ID(s): Q8IJ80

PDB ID(s): None

Isoelectric Point: 4.12

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
26292257 Discovery of Novel Plasmodium falciparum Pre-Erythrocytic Antigens for VaccineDevelopment. Aguiar JC, Bolton J, ..., Richie TL 10.1371/journal.pone.0136109
31728527 Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. Hoeijmakers WAM, Miao J, ..., Bartfai R 10.1093/nar/gkz1044