Genome location: Pf3D7_10_v3:1,313,214..1,315,135(-)
Genome classification: Core
Product Description: leucine-rich repeat protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000164 | protein phosphatase type 1 complex |
| Function | GO:0005515 | protein binding |
| Function | GO:0004865 | protein serine/threonine phosphatase inhibitor activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.97 |
| Trophozoite | expressed | 0.53 | 0.69 |
| Schizont | expressed | 0.30 | 0.80 |
| Gametocyte | not expressed | 0.49 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1032800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -2.804 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0516600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0516600)
Modification: Tagged | RMgm-5232
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3E1
"Best" AlphaFill ligand hit: URI (uridine, Local RMSD=1.75) with 4R07 (Global RMSD=8.86)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102267
Most Similar Human Ortholog: C9J177
TM-align score: 0.95 | RMSD: 1.27
Seq Identity: 0.42 | Length: 285 / 309
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115685 | protein phosphatase 1 regulatory subunit 7 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 16 | 7 | 21 |
| disruptive | 4 | 16 | 9 | 38 |
| missense | 3 | 14 | 9 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 30 | 11 | 22 |
| disruptive | 6 | 59 | 25 | 79 |
| missense | 5 | 43 | 19 | 52 |
PlasmoDB Total SNPs: 164
Non-coding: 146 | Synonymous: 16 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 309 | Molecular Weight (kDa): 36.506
PDB ID(s): None
Isoelectric Point: 7.96
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001611 | Leucine-rich repeat |
| InterPro | IPR003591 | Leucine-rich repeat, typical subtype |
| InterPro | IPR003603 | U2A'/phosphoprotein 32 family A, C-terminal |
| InterPro | IPR025875 | Leucine rich repeat 4 |
| PFam | PF12799 | Leucine rich repeat 4 |
| PFam | PF13855 | Leucine-rich repeat |
| Superfamily | SSF52058 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16629662 | Regulation of protein phosphatase type 1 and cell cycle progression by PfLRR1, anovel leucine-rich repeat protein of the human malaria parasite Plasmodiumfalciparum. | Daher W, Browaeys E, ..., Khalife J | 10.1111/j.1365-2958.2006.05119.x |
| 32671118 | The Protective Effect of Low Dose of Lipopolysaccharide Pretreatment onEndotoxin-Induced Uveitis in Rats Is Associated with Downregulation of CSF-1 andUpregulation of LRR-1 | Ling Y, Wang J, ..., Lu H | 10.1155/2020/9314756 |
| 35920043 | Plasmodium berghei leucine-rich repeat protein 1 downregulates proteinphosphatase 1 activity and is required for efficient oocyst development | Freville A, Gnangnon B, ..., Khalife J | 10.1098/rsob.220015 |