PF3D7_1032900

Genome location: Pf3D7_10_v3:1,315,145..1,321,148(-)

Genome classification: Core

Function and Localization

Product Description: RNA polymerase II-associated protein 1, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Process	GO:0006366	transcription by RNA polymerase II

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.48	0.77
Trophozoite	expressed	0.37	0.80
Schizont	expressed	0.10	0.94
Gametocyte	not expressed	0.57	0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1032900

Resistome Missense Mutations: N623K

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.103 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0516700)

Relative Growth Rate: 0.22 ± 0.22
Confidence: 4.43

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ79

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532820

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	28	84	60	119
disruptive	70	297	153	392
missense	51	268	142	349

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	37	193	75	128
disruptive	128	646	281	555
missense	85	538	235	396

PlasmoDB Total SNPs: 263

Non-coding: 70 | Synonymous: 111 | Nonsynonymous: 82 | Stop Codon: 0

Protein Information

Protein Length: 1743 | Molecular Weight (kDa): 207.854

UniProt ID(s): Q8IJ79

PDB ID(s): None

Isoelectric Point: 7.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013929	RNA polymerase II-associated protein 1, C-terminal
InterPro	IPR039913	RNA polymerase II-associated protein RPAP1/Rba50
PFam	PF08620	RNA polymerase II-associated protein 1, C-terminal
Superfamily	SSF101967	N/A