Genome location: Pf3D7_10_v3:1,321,359..1,323,742(+)
Genome classification: Core
Product Description: heptatricopeptide repeat-containing protein HPR1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003723 | RNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.17 | 0.92 |
| Trophozoite | expressed | 0.36 | 0.78 |
| Schizont | expressed | 0.15 | 0.90 |
| Gametocyte | expressed | 0.52 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1033000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.132 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0516800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0516800)
Modification: Tagged | RMgm-4463
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ78
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 29 | 15 | 59 |
| disruptive | 20 | 59 | 29 | 82 |
| missense | 11 | 50 | 26 | 65 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 70 | 25 | 59 |
| disruptive | 37 | 135 | 49 | 162 |
| missense | 17 | 110 | 36 | 114 |
PlasmoDB Total SNPs: 154
Non-coding: 81 | Synonymous: 35 | Nonsynonymous: 38 | Stop Codon: 0
Protein Length: 561 | Molecular Weight (kDa): 67.102
UniProt ID(s): Q8IJ78
PDB ID(s): None
Isoelectric Point: 9.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16507167 | Lineage-specific expansion of proteins exported to erythrocytes in malariaparasites. | Sargeant TJ, Marti M, ..., Cowman AF | 10.1186/gb-2006-7-2-r12 |
| 30102371 | Identification of clustered organellar short (cos) RNAs and of a conserved familyof organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in themalaria parasite. | Hillebrand A, Matz JM, ..., Schmitz-Linneweber C | 10.1093/nar/gky710 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 33147102 | R-loops at centromeric chromatin contribute to defects in kinetochore integrityand chromosomal instability in budding yeast | Mishra PK, Chakraborty A, ..., Basrai MA | 10.1091/mbc.E20-06-0379 |
| 33787496 | Cryo-EM structure of the yeast TREX complex and coordination with the SR-likeprotein Gbp2 | Xie Y, Clarke BP, ..., Ren Y | 10.7554/eLife.65699 |
| 33191913 | Structural insights into the nucleic acid remodeling mechanisms of the yeastTHO-Sub2 complex | Schuller SK, Schuller JM, ..., Conti E | 10.7554/eLife.61467 |