Genome location: Pf3D7_10_v3:1,333,997..1,336,551(+)
Genome classification: Core
Product Description: early transcribed membrane protein 10.2
SignalP Peptide: MKVGKIFFLLNILVVCHFIISCLC
# Transmembrane Domains: 2
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0005634 | nucleus |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.43 | 0.81 |
| Trophozoite | expressed | 1.24 | 0.43 |
| Schizont | expressed | 0.98 | 0.52 |
| Gametocyte | expressed | 0.92 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1033200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.511 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0517000)
Modification: Disrupted | RMgm-2016
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ76
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 8 | 8 | 20 |
| disruptive | 11 | 45 | 25 | 68 |
| missense | 10 | 43 | 25 | 59 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 25 | 12 | 22 |
| disruptive | 19 | 100 | 54 | 122 |
| missense | 15 | 92 | 48 | 83 |
PlasmoDB Total SNPs: 195
Non-coding: 171 | Synonymous: 11 | Nonsynonymous: 12 | Stop Codon: 1
Protein Length: 355 | Molecular Weight (kDa): 38.926
UniProt ID(s): C5HWR7, C5HWS2, C5HWS5, C5HWS9, C5HWT3, C5HWU0, C5HWU8, C5HWV1, C5HWV5, C5HWX6, Q8IJ76
PDB ID(s): None
Isoelectric Point: 10.08
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR006389 | Early transcribed membrane protein (ETRAMP) |
| PFam | PF09716 | Early transcribed membrane protein (ETRAMP) |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15671043 | Proteomic analysis identifies novel proteins of the Maurer's clefts, a secretorycompartment delivering Plasmodium falciparum proteins to the surface of its hostcell. | Vincensini L, Richert S, ..., Braun Breton C | 10.1074/mcp.M400176-MCP200 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |