About Gene List

PF3D7_1033300

Genome location: Pf3D7_10_v3:1,337,559..1,339,195(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.10 0.95
Trophozoite expressed 0.46 0.73
Schizont expressed 0.04 0.97
Gametocyte possibly expressed 0.16 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1033300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.151 | MFS: -2.963 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0517100)

  • Relative Growth Rate: 0.97 ± 0.18
  • Confidence: 4.78

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0517100)

Modification: Disrupted | RMgm-2017

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ75

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_140584

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 0
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 0 0 1
missense 0 0 0 0

PlasmoDB Total SNPs: 115

Non-coding: 113 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 122 | Molecular Weight (kDa): 14.43

UniProt ID(s): Q8IJ75

PDB ID(s): None

Isoelectric Point: 10.58

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108