Genome location: Pf3D7_10_v3:1,341,631..1,344,010(+)
Genome classification: Core
Product Description: WD repeat-containing protein 70, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Component | GO:0035861 | site of double-strand break |
| Process | GO:1903775 | regulation of DNA double-strand break processing |
| Process | GO:2001173 | regulation of histone H2B conserved C-terminal lysine ubiquitination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.57 | 0.73 |
| Trophozoite | possibly expressed | 0.54 | 0.68 |
| Schizont | possibly expressed | 0.29 | 0.80 |
| Gametocyte | expressed | 0.66 | 0.63 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1033500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.143 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ73
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102528
Most Similar Human Ortholog: D6RIW8
TM-align score: 0.55 | RMSD: 2.68
Seq Identity: 0.23 | Length: 234 / 709
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000082068 | WD repeat domain 70 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 42 | 18 | 40 |
| disruptive | 18 | 89 | 50 | 127 |
| missense | 15 | 82 | 49 | 113 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 64 | 33 | 44 |
| disruptive | 39 | 178 | 87 | 161 |
| missense | 27 | 157 | 80 | 131 |
PlasmoDB Total SNPs: 115
Non-coding: 20 | Synonymous: 60 | Nonsynonymous: 35 | Stop Codon: 0
Protein Length: 709 | Molecular Weight (kDa): 83.23
UniProt ID(s): Q8IJ73
PDB ID(s): None
Isoelectric Point: 6.62
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32007529 | Wdr70 regulates histone modification and genomic maintenance in fission yeast | Zeng M, Tang Z, ..., Liu C | 10.1016/j.bbamcr.2020.118665 |