Genome location: Pf3D7_10_v3:1,344,081..1,347,509(-)
Genome classification: Core
Product Description: pre-mRNA-splicing factor CEF1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000974 | Prp19 complex |
| Component | GO:0071006 | U2-type catalytic step 1 spliceosome |
| Component | GO:0005634 | nucleus |
| Function | GO:0003677 | DNA binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0000398 | mRNA splicing, via spliceosome |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.98 | 0.57 |
| Trophozoite | expressed | 0.90 | 0.52 |
| Schizont | expressed | 0.36 | 0.79 |
| Gametocyte | expressed | 0.59 | 0.67 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1033600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.012 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KQL1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102607
Most Similar Human Ortholog: Q99459
TM-align score: 0.36 | RMSD: 5.69
Seq Identity: 0.49 | Length: 346 / 915
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000096401 | cell division cycle 5 like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 13 | 62 | 28 | 62 |
| disruptive | 27 | 118 | 61 | 152 |
| missense | 16 | 101 | 59 | 146 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 103 | 27 | 76 |
| disruptive | 44 | 215 | 108 | 190 |
| missense | 25 | 196 | 102 | 166 |
PlasmoDB Total SNPs: 101
Non-coding: 25 | Synonymous: 49 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 915 | Molecular Weight (kDa): 108.411
PDB ID(s): None
Isoelectric Point: 6.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001005 | SANT/Myb domain |
| InterPro | IPR009057 | Homeobox-like domain superfamily |
| InterPro | IPR021786 | Pre-mRNA splicing factor component Cdc5p/Cef1 |
| PFam | PF11831 | Pre-mRNA splicing factor component Cdc5p/Cef1 |
| PFam | PF13921 | |
| Superfamily | SSF46689 | Homeobox-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 21530591 | A densely overlapping gene fragmentation approach improves yeast two-hybridscreens for Plasmodium falciparum proteins. | Brown HF, Wang L, ..., LaCount DJ | 10.1016/j.molbiopara.2011.04.005 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 19789211 | A systematic characterization of Cwc21, the yeast ortholog of the humanspliceosomal protein SRm300 | Khanna M, Van Bakel H, ..., Blencowe BJ | 10.1261/rna.1790509 |
| 27368340 | A protein map of the yeast activated spliceosome as obtained by electronmicroscopy | Sun C, Rigo N, ..., Luhrmann R | 10.1261/rna.057778.116 |