Genome location: Pf3D7_10_v3:1,347,681..1,350,687(+)
Genome classification: Core
Product Description: bromodomain protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000781 | chromosome, telomeric region |
| Component | GO:0005634 | nucleus |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0042393 | histone binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0044409 | entry into host |
| Process | GO:0006355 | regulation of transcription, DNA-templated |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.64 | 0.70 |
| Trophozoite | expressed | 0.83 | 0.55 |
| Schizont | expressed | 0.20 | 0.87 |
| Gametocyte | expressed | 0.62 | 0.66 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1033700
Resistome Missense Mutations: V294L
Resistome Compounds with Missense Mutations: MMV676881
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.169 | MFS: -3.254 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0517500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ72
"Best" AlphaFill ligand hit: TAR (d(-)-tartaric acid, Local RMSD=0.18) with 6MOJ (Global RMSD=4.87)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q58F21 | Bromodomain testis-specific protein | Homo sapiens | OrthoDB | (6S+2S)-PEG1 (7)(6S+2S)-PEG1 (7)(6S+2S)-PEG1 (7)MTI (35)... |
| Q15059 | Bromodomain-containing protein 3 | OrthoDB | US8975417, 3US8975417, 5US8975417, 6US8975417, 7... | |
| P25440 | Bromodomain-containing protein 2 | OrthoDB | US8975417, 3US8975417, 5US8975417, 6US8975417, 7... | |
| Q9ESU6 | Bromodomain-containing protein 4 | Mus musculus | OrthoDB | CHEMBL3086885CHEMBL3086883CHEMBL3086885CHEMBL3086883 |
| O60885 | Bromodomain-containing protein 4 | OrthoDB | US8975417, 1US8975417, 2US8975417, 3US8975417, 4... |
Protein Length: 488 | Molecular Weight (kDa): 55.937
UniProt ID(s): Q8IJ72
Isoelectric Point: 5.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001487 | Bromodomain |
| InterPro | IPR002110 | Ankyrin repeat |
| InterPro | IPR018359 | Bromodomain, conserved site |
| InterPro | IPR020683 | Ankyrin repeat-containing domain |
| InterPro | IPR036427 | Bromodomain-like superfamily |
| InterPro | IPR036770 | Ankyrin repeat-containing domain superfamily |
| PFam | PF00439 | Bromodomain |
| PFam | PF12796 | Ankyrin repeat-containing domain |
| PFam | PF13637 | |
| Superfamily | SSF47370 | Bromodomain-like superfamily |
| Superfamily | SSF48403 | Ankyrin repeat-containing domain superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 33 | 13 | 34 |
| disruptive | 4 | 28 | 19 | 38 |
| missense | 3 | 28 | 19 | 35 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 56 | 23 | 27 |
| disruptive | 8 | 58 | 36 | 70 |
| missense | 6 | 48 | 32 | 51 |
PlasmoDB Total SNPs: 135
Non-coding: 108 | Synonymous: 18 | Nonsynonymous: 9 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 26067602 | A Plasmodium Falciparum Bromodomain Protein Regulates Invasion Gene Expression. | Josling GA, Petter M, ..., Duffy MF | 10.1016/j.chom.2015.05.009 |
| 28376558 | Pf AP2Tel, harbouring a non-canonical D NA-binding A P2 domain, binds to Plasmodiumfalciparum telomeres | Sierra-Miranda M, Vembar SS, ..., Hernandez-Rivas R | 10.1111/cmi.12742 |
| 28618269 | Red Blood Cell Invasion by the Malaria Parasite Is Coordinated by the PfAP2-ITranscription Factor. | Santos JM, Josling G, ..., Llinas M | 10.1016/j.chom.2017.05.006 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 35493110 | The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite PlasmodiumFalciparum Cooperates With PfBDP1 in the Silencing of Variant Surface AntigenExpression. | Quinn JE, Jeninga MD, ..., Petter M | 10.3389/fcell.2022.816558 |
| 37349497 | A type II protein arginine methyltransferase regulates merozoite invasion in Plasmodium falciparum | Lucky AB, Wang C, ..., Miao J | 10.1038/s42003-023-05038-z |
| 36328269 | Structural insights into acetylated histone ligand recognition by the BDP1bromodomain of Plasmodium falciparum | Singh AK, Phillips M, ..., Glass KC | 10.1016/j.ijbiomac.2022.10.247 |
| 34403450 | A unique GCN5 histone acetyltransferase complex controls erythrocyte invasion andvirulence in the malaria parasite Plasmodium falciparum | Miao J, Wang C, ..., Cui L | 10.1371/journal.ppat.1009351 |