Genome location: Pf3D7_10_v3:1,359,257..1,361,309(-)
Genome classification: Core
Product Description: Sec1 family protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000139 | Golgi membrane |
| Component | GO:0005829 | cytosol |
| Function | GO:0019905 | syntaxin binding |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006886 | intracellular protein transport |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.16 | 0.92 |
| Trophozoite | possibly expressed | 0.38 | 0.76 |
| Schizont | expressed | 0.28 | 0.81 |
| Gametocyte | possibly expressed | 0.29 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1034000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.144 | MFS: -3.254 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0517800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0517800)
Modification: Disrupted | RMgm-2022
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ69
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101825
Most Similar Human Ortholog: Q8WVM8
TM-align score: 0.89 | RMSD: 2.93
Seq Identity: 0.31 | Length: 618 / 663
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000092108 | sec1 family domain containing 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 38 | 21 | 29 |
| disruptive | 11 | 29 | 20 | 53 |
| missense | 5 | 26 | 18 | 45 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 73 | 25 | 49 |
| disruptive | 20 | 92 | 60 | 120 |
| missense | 9 | 69 | 49 | 85 |
PlasmoDB Total SNPs: 28
Non-coding: 1 | Synonymous: 17 | Nonsynonymous: 10 | Stop Codon: 0
Protein Length: 663 | Molecular Weight (kDa): 76.827
UniProt ID(s): Q8IJ69
PDB ID(s): None
Isoelectric Point: 7.82
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001619 | Sec1-like protein |
| InterPro | IPR036045 | Sec1-like superfamily |
| PFam | PF00995 | Sec1-like protein |
| Superfamily | SSF56815 | Sec1-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 37209206 | Overexpression of genes by stress-responsive promoters increases proteinsecretion in Saccharomyces cerevisiae | Xiao C, Xue S, ..., Huang M | 10.1007/s11274-023-03646-9 |