Genome location: Pf3D7_10_v3:1,363,474..1,364,118(+)
Genome classification: Core
Product Description: ribosomal protein L27, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000311 | plastid large ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | possibly expressed | 0.09 | 0.94 |
| Schizont | expressed | 0.06 | 0.95 |
| Gametocyte | expressed | 0.25 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1034200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.492 | MFS: -2.25 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ68
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101181
Most Similar Human Ortholog: D6RAN8
TM-align score: 0.57 | RMSD: 1.31
Seq Identity: 0.30 | Length: 56 / 214
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000108826 | mitochondrial ribosomal protein L27 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 15 | 5 | 11 |
| disruptive | 4 | 13 | 15 | 29 |
| missense | 4 | 12 | 14 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 26 | 3 | 16 |
| disruptive | 7 | 46 | 22 | 48 |
| missense | 5 | 38 | 22 | 40 |
PlasmoDB Total SNPs: 3
Non-coding: 0 | Synonymous: 2 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 214 | Molecular Weight (kDa): 24.891
UniProt ID(s): Q8IJ68
PDB ID(s): None
Isoelectric Point: 11
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001684 | Ribosomal protein L27 |
| InterPro | IPR018261 | Ribosomal protein L27, conserved site |
| PFam | PF01016 | Ribosomal protein L27 |
| Superfamily | SSF110324 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |