Genome location: Pf3D7_10_v3:1,365,099..1,366,691(+)
Genome classification: Core
Product Description: thioredoxin-like associated protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005875 | microtubule associated complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | possibly expressed | 0.04 | 0.98 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | expressed | 0.20 | 0.88 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1034300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.869 | MFS: -2.634 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0518100)
Modification: Disrupted | RMgm-2023
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ67
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 34 | 10 | 26 |
| disruptive | 14 | 73 | 46 | 81 |
| missense | 9 | 69 | 44 | 80 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 55 | 21 | 31 |
| disruptive | 32 | 148 | 66 | 122 |
| missense | 22 | 139 | 56 | 91 |
PlasmoDB Total SNPs: 36
Non-coding: 0 | Synonymous: 16 | Nonsynonymous: 20 | Stop Codon: 0
Protein Length: 530 | Molecular Weight (kDa): 62.571
UniProt ID(s): Q8IJ67
PDB ID(s): None
Isoelectric Point: 10.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | SSF101898 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23873863 | Novel thioredoxin-like proteins are components of a protein complex coating thecortical microtubules of Toxoplasma gondii. | Liu J, Wetzel L, ..., Hu K | 10.1128/EC.00082-13 |