PF3D7_1034500

Genome location: Pf3D7_10_v3:1,369,717..1,376,708(+)

Genome classification: Core

Function and Localization

Product Description: armadillo repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0008287	protein serine/threonine phosphatase complex
Function	GO:0019888	protein phosphatase regulator activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.07	0.97
Trophozoite	expressed	0.67	0.63
Schizont	expressed	0.47	0.73
Gametocyte	expressed	0.26	0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1034500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.161 | MFS: -2.851 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0518300)

Relative Growth Rate: 1.02 ± 0.16
Confidence: 5.03

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0518300)

Modification: Disrupted | RMgm-2025

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ65

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102869

Most Similar Human Ortholog: J3QL26

TM-align score: 0.81 | RMSD: 2.21

Seq Identity: 0.16 | Length: 132 / 1511

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000154845	protein phosphatase 4 regulatory subunit 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	30	76	30	76
disruptive	102	212	106	225
missense	61	180	98	193

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	46	117	49	94
disruptive	153	384	178	355
missense	90	323	146	268

PlasmoDB Total SNPs: 317

Non-coding: 162 | Synonymous: 76 | Nonsynonymous: 79 | Stop Codon: 0

Protein Information

Protein Length: 1511 | Molecular Weight (kDa): 180.847

UniProt ID(s): Q8IJ65

PDB ID(s): None

Isoelectric Point: 6.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR016024	Armadillo-type fold
PFam	N/A	N/A
Superfamily	SSF48371	Armadillo-type fold

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104