Genome location: Pf3D7_10_v3:1,376,452..1,377,978(-)
Genome classification: Core
Product Description: translation initiation factor IF-3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.09 | 0.96 |
| Trophozoite | expressed | 0.76 | 0.59 |
| Schizont | expressed | 0.85 | 0.52 |
| Gametocyte | expressed | 0.58 | 0.69 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1034600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -3.087 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ64
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 7 | 4 | 11 |
| disruptive | 5 | 36 | 16 | 41 |
| missense | 5 | 34 | 15 | 39 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 10 | 8 | 17 |
| disruptive | 13 | 71 | 24 | 69 |
| missense | 10 | 60 | 21 | 42 |
PlasmoDB Total SNPs: 55
Non-coding: 31 | Synonymous: 14 | Nonsynonymous: 8 | Stop Codon: 2
Protein Length: 310 | Molecular Weight (kDa): 37.576
UniProt ID(s): Q8IJ64
PDB ID(s): None
Isoelectric Point: 10.38
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036788 | Translation initiation factor 3 (IF-3), C-terminal domain superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF55200 | Translation initiation factor 3 (IF-3), C-terminal domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25689481 | Targeting and function of proteins mediating translation initiation in organellesof Plasmodium falciparum. | Haider A, Allen SM, ..., Habib S | 10.1111/mmi.12972 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |