PF3D7_1034700

Genome location: Pf3D7_10_v3:1,378,257..1,379,876(+)

Genome classification: Core

Function and Localization

Product Description: ADP-ribosylation factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Component	GO:0005737	cytoplasm
Function	GO:0005525	GTP binding
Process	GO:0006886	intracellular protein transport
Process	GO:0016192	vesicle-mediated transport

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.09	0.94
Schizont	expressed	0.20	0.86
Gametocyte	expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1034700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.49 | MFS: -2.895 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0518500)

Relative Growth Rate: 1.00 ± 0.07
Confidence: 6.76

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0518500)

Modification: Disrupted | RMgm-2026

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ63

"Best" AlphaFill ligand hit: BEZ (benzoic acid, Local RMSD=0.03) with 1S8F (Global RMSD=4.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103249

Most Similar Human Ortholog: P40616

TM-align score: 0.94 | RMSD: 1.79

Seq Identity: 0.61 | Length: 178 / 178

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000120805	ADP ribosylation factor like GTPase 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 89

Non-coding: 83 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 178 | Molecular Weight (kDa): 20.248

UniProt ID(s): O00818, Q8IJ63, Q9U464

PDB ID(s): None

Isoelectric Point: 8.79

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005225	Small GTP-binding protein domain
InterPro	IPR006689	Small GTPase superfamily, ARF/SAR type
InterPro	IPR027417	P-loop containing nucleoside triphosphate hydrolase
PFam	PF00025	Small GTPase superfamily, ARF/SAR type
Superfamily	SSF52540	P-loop containing nucleoside triphosphate hydrolase