About Gene List

PF3D7_1035100

Genome location: Pf3D7_10_v3:1,391,390..1,393,405(+)

Genome classification: Core

Function and Localization

Product Description: probable protein, unknown function

SignalP Peptide: MNKIWNITFCLLFQYLCIFQNKVST

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.03 0.99
Trophozoite expressed 0.09 0.94
Schizont expressed 0.94 0.54
Gametocyte expressed 0.17 0.90

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1035100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.925 | MFS: -2.293 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ58

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532737

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 7 7 13
disruptive 53 49 31 79
missense 53 46 24 57

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 14 8 22
disruptive 65 105 52 102
missense 59 88 43 65

PlasmoDB Total SNPs: 108

Non-coding: 26 | Synonymous: 31 | Nonsynonymous: 51 | Stop Codon: 0

Protein Information

Protein Length: 561 | Molecular Weight (kDa): 64.879

UniProt ID(s): D9HMV8, D9HMW1, D9HMW4, D9HMZ1, D9HMZ3, D9HMZ5, D9HN01, D9HN06, D9HN17, D9HN26, Q8IJ58

PDB ID(s): None

Isoelectric Point: 4.92

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104