Product Description: S-antigen
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020003 | symbiont-containing vacuole |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.38 | 0.83 |
| Trophozoite | expressed | 0.61 | 0.73 |
| Schizont | expressed | 4.43 | 0.05 |
| Gametocyte | possibly expressed | 0.13 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1035200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: -1.218 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q03400
"Best" AlphaFill ligand hit: HEM (heme, Local RMSD=0.24) with 2O6P (Global RMSD=17.41)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_116069
Most Similar Human Ortholog: Q7Z2K8
TM-align score: 0.12 | RMSD: 7.47
Seq Identity: 0.09 | Length: 111 / 585
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000169258 | G protein regulated inducer of neurite outgrowth 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 0 | 0 | 2 |
| disruptive | 29 | 11 | 3 | 12 |
| missense | 26 | 9 | 1 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 0 | 0 | 3 |
| disruptive | 29 | 11 | 5 | 19 |
| missense | 26 | 9 | 3 | 9 |
PlasmoDB Total SNPs: 652
Non-coding: 415 | Synonymous: 15 | Nonsynonymous: 222 | Stop Codon: 0
Protein Length: 585 | Molecular Weight (kDa): 62.947
UniProt ID(s): A0A143ZZC7, Q03400, Q26012, Q26013, Q26014, Q9GN76, Q9GN91, Q9GZ78, Q9GZ81, Q9GZ86, Q9GZ96, Q9GZ99
PDB ID(s): None
Isoelectric Point: 4.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008825 | S-antigen |
| PFam | PF05756 | S-antigen |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 2406433 | S-antigen localization in the erythrocytic stages of Plasmodium falciparum. | Culvenor JG, Crewther PE | 10.1111/j.1550-7408.1990.tb01117.x |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |