Genome location: Pf3D7_10_v3:1,398,801..1,403,741(+)
Genome classification: Core
Product Description: glutamate-rich protein GLURP
SignalP Peptide: MRNLFHITICLVTLNLFILEINA
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020003 | symbiont-containing vacuole |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.09 | 0.96 |
| Trophozoite | possibly expressed | 0.07 | 0.96 |
| Schizont | expressed | 1.99 | 0.36 |
| Gametocyte | expressed | 0.13 | 0.92 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1035300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.996 | MFS: -1.886 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ56
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 19 | 22 | 11 | 22 |
| disruptive | 79 | 108 | 39 | 111 |
| missense | 74 | 91 | 33 | 96 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 21 | 37 | 8 | 29 |
| disruptive | 97 | 161 | 57 | 151 |
| missense | 88 | 126 | 55 | 119 |
PlasmoDB Total SNPs: 263
Non-coding: 65 | Synonymous: 96 | Nonsynonymous: 102 | Stop Codon: 0
Protein Length: 1233 | Molecular Weight (kDa): 141.051
UniProt ID(s): A0A060CSD6, A0A060CSE0, A0A060CSF1, A0A060CVV7, A0A060CWF2, A0A060D170, A0A060D181, A0A060D1Y6, A0A060D1Z2, A0A068J736, A0A223LVD2, A0A223LVE2, A0A223LVE6, A0A223LVE9, A0A223LVG0, A0A223LVG1, A0A223LVG8, A0A223LVG9, A0A2L0P0V6, Q25860, Q8I0H2, Q8IJ56, Q9GTX2, Q9TVJ5, Q9TVY9, Q9U0Q8, Q9U0R4, Q9U4B2, Q9U4B3, V5NRK8, V5NS09, V5NS28, V5RF61
PDB ID(s): None
Isoelectric Point: 3.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 1775153 | Primary structure and localization of a conserved immunogenic Plasmodiumfalciparum glutamate rich protein (GLURP) expressed in both the preerythrocyticand erythrocytic stages of the vertebrate life cycle. | Borre MB, Dziegiel M, ..., et al. | 10.1016/0166-6851(91)90135-s |
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 28202027 | A novel Pfs38 protein complex on the surface of Plasmodium falciparum blood-stagemerozoites. | Paul G, Deshmukh A, ..., Malhotra P | 10.1186/s12936-017-1716-0 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30092030 | SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN4.2-RON4-GLURP)contributes to merozoite invasion. | Quintana MDP, Ch'ng JH, ..., Wahlgren M | 10.1371/journal.pone.0201669 |
| 37751696 | A genomic platform for surveillance and antigen discovery in Plasmodium spp.using long-read amplicon sequencing | Plaza DF, Zerebinski J, ..., Farnert A | 10.1016/j.crmeth.2023.100574 |
| 36711279 | Susceptibility to malaria in fulani, Bariba, Otamari and gando individuals livingin sympatry in Benin: Role of opsonizing antibodies to Plasmodium falciparummerozoites | Fall AKDJ, Kana IH, ..., Courtin D | 10.1016/j.heliyon.2023.e13092 |
| 38281044 | msp1, msp2, and glurp genotyping to differentiate Plasmodium falciparumrecrudescence from reinfections during prevention of reestablishment phase, SriLanka, 2014-2019 | Gunasekera KT, Premaratne RG, ..., Fernando DS | 10.1186/s12936-024-04858-6 |
| 36071520 | Efficacy of three anti-malarial regimens for uncomplicated Plasmodium falciparummalaria in Cambodia, 2009-2011: a randomized controlled trial and brief review | Lek D, Rachmat A, ..., Rogers WO | 10.1186/s12936-022-04279-3 |
| 36447200 | Naturally acquired antibodies from Beninese infants promote Plasmodium falciparummerozoite-phagocytosis by human blood leukocytes: implications for control ofasymptomatic malaria infections | Fall AKDJ, Kana IH, ..., Courtin D | 10.1186/s12936-022-04361-w |
| 37545953 | Genetic diversity of Plasmodium falciparum among asymptomatic pregnant women onintermittent preventive treatment with sulfadoxine-pyrimethamine in Nigeria | Olowe RA, Ojo JA, ..., Ojurongbe O | 10.4314/ahs.v23i1.80 |
| 36109748 | Temporal dynamics of Plasmodium falciparum population in Metehara, east-centralEthiopia | Reda AG, Messele A, ..., Mamo H | 10.1186/s12936-022-04277-5 |
| 38290009 | A randomized first-in-human Phase 1 trial of differentially adjuvanted Pfs48/45malaria vaccines in Burkinabe adults | Tiono BA, Plieskatt JL, ..., Theisen M | 10.1172/JCI175707 |
| 38350548 | Genetic diversity of glutamate-rich protein (GLURP) in Plasmodium falciparumisolates from school-age children in Kinshasa, DRC | Paul KMM, Simpson SV, ..., Yamamoto T | 10.1016/j.parint.2024.102866 |
| 35883064 | Etramp5 as a useful serological marker in children to assess the immediateeffects of mass drug campaigns for malaria | Druetz T, van den Hoogen L, ..., Eisele TP | 10.1186/s12879-022-07616-8 |
| 36812236 | Effects of anti-malarial prophylaxes on maternal transfer of Immunoglobulin-G(IgG) and association to immunity against Plasmodium falciparum infections amongchildren in a Ugandan birth cohort | Okek EJ, Ocan M, ..., Kamya MR | 10.1371/journal.pone.0277789 |
| 35883089 | DNA recovery from used malaria RDT to detect Plasmodium species and to assessPlasmodium falciparum genetic diversity: a pilot study in Madagascar | Andrianaranjaka VHI, Ravaoarisoa E, ..., Ratsimbasoa A | 10.1186/s12936-022-04246-y |
| 36499205 | Fc Gamma Receptor IIIB NA1/NA2/SH Polymorphisms Are Associated with MalariaSusceptibility and Antibody Levels to P. falciparum Merozoite Antigens inBeninese Children | Fall AKDJ, Courtin D, ..., Dechavanne C | 10.3390/ijms232314882 |
| 37689681 | Plasmodium falciparum population structure inferred by msp1 amplicon sequencingof parasites collected from febrile patients in Kenya | Andika B, Mobegi V, ..., Waitumbi J | 10.1186/s12936-023-04700-5 |
| 37501921 | Plasmodium falciparum infection and naturally acquired immunity to malariaantigens among Ghanaian children in northern Ghana | Seidu Z, Lamptey H, ..., Ofori MF | 10.1016/j.parepi.2023.e00317 |
| 37456906 | Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P.falciparum diversity throughout treatment in a clinical drug trial | Wamae K, Ndwiga L, ..., Ochola-Oyier L | 10.12688/wellcomeopenres.17736.2 |
| 37553646 | Evolution of genetic markers for drug resistance after the introduction ofdihydroartemisinin-piperaquine as first-line anti-malarial treatment foruncomplicated falciparum malaria in Indonesia | Rahmasari FV, Asih PBS, ..., Syafruddin D | 10.1186/s12936-023-04658-4 |
| 36851323 | B-Cell Epitope Mapping of the Plasmodium falciparum Malaria Vaccine CandidateGMZ2.6c in a Naturally Exposed Population of the Brazilian Amazon | Baptista BO, Souza ABL, ..., Pratt-Riccio LR | 10.3390/vaccines11020446 |
| 36510009 | High prevalence of persistent residual parasitemia on days 3 and 14 afterartemether-lumefantrine or pyronaridine-artesunate treatment of uncomplicatedPlasmodium falciparum malaria in Nigeria | Funwei RI, Uyaiabasi GN, ..., Falade CO | 10.1007/s00436-022-07753-8 |