Genome location: Pf3D7_10_v3:1,406,658..1,409,053(+)
Genome classification: Core
Product Description: merozoite surface protein 6
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Function | GO:0046812 | host cell surface binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0044877 | protein-containing complex binding |
| Process | GO:0044409 | entry into host |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.37 | 0.87 |
| Trophozoite | expressed | 0.09 | 0.95 |
| Schizont | expressed | 1.27 | 0.60 |
| Gametocyte | possibly expressed | 0.04 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1035500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.565 | MFS: -2.477 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ54
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 7 | 1 | 11 |
| disruptive | 45 | 41 | 16 | 76 |
| missense | 34 | 33 | 8 | 53 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 9 | 10 | 14 |
| disruptive | 59 | 66 | 37 | 84 |
| missense | 42 | 47 | 29 | 48 |
PlasmoDB Total SNPs: 105
Non-coding: 48 | Synonymous: 25 | Nonsynonymous: 32 | Stop Codon: 0
Protein Length: 371 | Molecular Weight (kDa): 42.275
UniProt ID(s): B7SJH5, B7SJH6, B7SJH7, B7SJH8, B7SJI0, B7SJI2, C6ZGD0, C6ZGD8, Q6R1M1, Q8IJ54, Q9GS22
PDB ID(s): None
Isoelectric Point: 4.03
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR010784 | Merozoite surface protein-type |
| PFam | PF07133 | Merozoite surface protein-type |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 16713025 | Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides binderythrocytes and partially inhibit parasite invasion. | Lopez R, Valbuena J, ..., Patarroyo ME | 10.1016/j.peptides.2006.02.001 |
| 16940297 | Interactions between merozoite surface proteins 1, 6, and 7 of the malariaparasite Plasmodium falciparum. | Kauth CW, Woehlbier U, ..., Bujard H | 10.1074/jbc.M604641200 |
| 19463923 | Sequence diversity and evolutionary dynamics of the dimorphic antigen merozoitesurface protein-6 and other Msp genes of Plasmodium falciparum. | Roy SW, Weedall GD, ..., Ferreira MU | 10.1016/j.gene.2009.05.007 |
| 20497564 | Limited variation in vaccine candidate Plasmodium falciparum Merozoite SurfaceProtein-6 over multiple transmission seasons. | Neal AT, Jordan SJ, ..., Rayner JC | 10.1186/1475-2875-9-138 |
| 25074930 | The merozoite surface protein 1 complex is a platform for binding to humanerythrocytes by Plasmodium falciparum. | Lin CS, Uboldi AD, ..., Cowman AF | 10.1074/jbc.M114.586495 |
| 26823464 | Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes MediateMerozoite Binding to Human Erythrocytes. | Lin CS, Uboldi AD, ..., Cowman AF | 10.1074/jbc.M115.698282 |
| 29760216 | Plasmodium falciparum M SP3 Exists in a Complex on the Merozoite Surface and Generates Antibody Response during Natural Infection | Deshmukh A, Chourasia BK, ..., Malhotra P | 10.1128/IAI.00067-18 |
| 31964745 | Peripheral Merozoite Surface Proteins Are Targets of Naturally Acquired Immunityagainst Malaria in both India and Ghana | Garcia-Senosiain A, Kana IH, ..., Theisen M | 10.1128/IAI.00778-19 |
| 15664649 | Characterisation of two novel proteins from the asexual stage of Plasmodiumfalciparum, H101 and H103 | Pearce JA, Mills K, ..., Anders RF | 10.1016/j.molbiopara.2004.09.012 |
| 19404387 | A conserved multi-gene family induces cross-reactive antibodies effective indefense against Plasmodium falciparum | Singh S, Soe S, ..., Druilhe P | 10.1371/journal.pone.0005410 |
| 19884337 | Toward the rational design of a malaria vaccine construct using the MSP3 familyas an example: contribution of antigenicity studies in humans | Demanga CG, Daher LJ, ..., Druilhe P | 10.1128/IAI.01359-08 |
| 26296605 | The Plasmodium gaboni genome illuminates allelic dimorphism of immunologicallyimportant surface antigens in P. falciparum | Roy SW | 10.1016/j.meegid.2015.08.014 |
| 20564187 | Conserved regions from Plasmodium falciparum MSP11 specifically interact withhost cells and have a potential role during merozoite invasion of red bloodcells | Obando-Martinez AZ, Curtidor H, ..., Patarroyo ME | 10.1002/jcb.22600 |
| 15664972 | Plasmodium falciparum merozoite surface protein 6 displays multiple targets fornaturally occurring antibodies that mediate monocyte-dependent parasite killing | Singh S, Soe S, ..., Druilhe P | 10.1128/IAI.73.2.1235-1238.2005 |
| 15339842 | Disruption of Plasmodium berghei merozoite surface protein 7 gene modulatesparasite growth in vivo | Tewari R, Ogun SA, ..., Holder AA | 10.1182/blood-2004-06-2106 |
| 20451527 | Merozoite surface proteins of the malaria parasite: the MSP1 complex and the MSP7family | Kadekoppala M, Holder AA | 10.1016/j.ijpara.2010.04.008 |
| 15582517 | The alanine-rich heptad repeats are intact in the processed form of Plasmodiumfalciparum MSP3 | Pearce JA, Hodder AN, Anders RF | 10.1016/j.exppara.2004.07.017 |
| 20298576 | Antibodies against multiple merozoite surface antigens of the human malariaparasite Plasmodium falciparum inhibit parasite maturation and red blood cellinvasion | Woehlbier U, Epp C, ..., Bujard H | 10.1186/1475-2875-9-77 |
| 19214190 | A multifunctional serine protease primes the malaria parasite for red blood cellinvasion | Koussis K, Withers-Martinez C, ..., Blackman MJ | 10.1038/emboj.2009.22 |
| 18820076 | Deletion of the Plasmodium falciparum merozoite surface protein 7 gene impairsparasite invasion of erythrocytes | Kadekoppala M, O'Donnell RA, ..., Holder AA | 10.1128/EC.00274-08 |
| 27185785 | Merozoite Antigens of Plasmodium falciparum Elicit Strain-Transcending OpsonizingImmunity | Hill DL, Wilson DW, ..., Schofield L | 10.1128/IAI.00145-16 |