PF3D7_1035600 (H101)

Genome location: Pf3D7_10_v3:1,409,095..1,410,806(+)

Genome classification: Core

Function and Localization

Product Description: merozoite surface protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.03	0.98
Schizont	expressed	0.58	0.66
Gametocyte	not expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1035600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.999 | MFS: -2.559 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ53

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532981

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	11	9	9
disruptive	16	41	28	59
missense	13	35	25	51

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	14	8	15
disruptive	29	82	32	70
missense	23	67	27	58

PlasmoDB Total SNPs: 77

Non-coding: 45 | Synonymous: 9 | Nonsynonymous: 21 | Stop Codon: 2

Protein Information

Protein Length: 424 | Molecular Weight (kDa): 48.196

UniProt ID(s): C5HEG4, C5HEG5, C5HEG7, C5HEG8, C5HEG9, C5HEH0, C5HEH1, C5HEH3, C5HEH4, C5HEH8, Q8IJ53

PDB ID(s): None

Isoelectric Point: 4.36

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR010784	Merozoite surface protein-type
PFam	PF07133	Merozoite surface protein-type
Superfamily	N/A	N/A