Genome location: Pf3D7_10_v3:1,412,641..1,416,363(+)
Genome classification: Core
Product Description: duffy binding-like merozoite surface protein
SignalP Peptide: MKKIYSIFFSLFILNLHIYIKNIKC
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:1903561 | extracellular vesicle |
| Function | GO:0001791 | IgM binding |
| Function | GO:0046812 | host cell surface binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0044409 | entry into host |
| Process | GO:0009657 | plastid organization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.11 | 0.95 |
| Trophozoite | not expressed | 0.23 | 0.87 |
| Schizont | expressed | 2.11 | 0.21 |
| Gametocyte | not expressed | 0.03 | 0.98 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1035700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.342 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8IJ52
"Best" AlphaFill ligand hit: 3PO (triphosphate, Local RMSD=2.66) with 5MZA (Global RMSD=4.24)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 17 | 6 | 13 |
| disruptive | 72 | 51 | 50 | 81 |
| missense | 53 | 39 | 41 | 60 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 16 | 25 | 13 | 22 |
| disruptive | 88 | 114 | 55 | 107 |
| missense | 62 | 93 | 42 | 74 |
PlasmoDB Total SNPs: 205
Non-coding: 62 | Synonymous: 45 | Nonsynonymous: 95 | Stop Codon: 3
Protein Length: 697 | Molecular Weight (kDa): 80.248
UniProt ID(s): A0A193PC04, A0A193PC26, A0A193PCV3, A0A193PCW1, A0A193PCW2, A0A193PCW5, A0A193PCY0, A0A193PCZ0, A0A193PD00, A0A193PDJ5, C5HEI5, C5HEI7, C5HEI8, C5HEI9, C5HEJ0, C5HEJ1, C5HEJ2, C5HEJ5, C5HEJ6, C5HWZ6, C5HX11, C5HX14, C5HX20, C5HX25, C5HX28, C5HX41, C5HX43, C5HY28, D9HN48, Q8IJ52
PDB ID(s): None
Isoelectric Point: 4.72
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008602 | Duffy-antigen binding |
| InterPro | IPR010784 | Merozoite surface protein-type |
| PFam | PF05424 | Duffy-antigen binding |
| PFam | PF07133 | Merozoite surface protein-type |
| Superfamily | SSF140924 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 19367830 | A novel Plasmodium falciparum erythrocyte binding protein associated with themerozoite surface, PfDBLMSP. | Wickramarachchi T, Cabrera AL, ..., Mohmmed A | 10.1016/j.ijpara.2008.12.004 |
| 20037583 | Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. | Hu G, Cabrera A, ..., Bozdech Z | 10.1038/nbt.1597 |
| 22248820 | Antibodies against a Plasmodium falciparum antigen PfMSPDBL1 inhibit merozoiteinvasion into human erythrocytes. | Sakamoto H, Takeo S, ..., Tsuboi T | 10.1016/j.vaccine.2012.01.010 |
| 25074930 | The merozoite surface protein 1 complex is a platform for binding to humanerythrocytes by Plasmodium falciparum. | Lin CS, Uboldi AD, ..., Cowman AF | 10.1074/jbc.M114.586495 |
| 26823464 | Multiple Plasmodium falciparum Merozoite Surface Protein 1 Complexes MediateMerozoite Binding to Human Erythrocytes. | Lin CS, Uboldi AD, ..., Cowman AF | 10.1074/jbc.M115.698282 |
| 27226583 | Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 toHuman Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants. | Crosnier C, Iqbal Z, ..., Wright GJ | 10.1074/jbc.M116.722074 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 37156765 | Plasmodium falciparum has evolved multiple mechanisms to hijack humanimmunoglobulin M | Ji C, Shen H, ..., Xiao J | 10.1038/s41467-023-38320-z |