PF3D7_1035800 (M712)

Genome location: Pf3D7_10_v3:1,419,703..1,423,290(+)

Genome classification: Core

Function and Localization

Product Description: probable protein, unknown function

SignalP Peptide: MKYILSISLFLILLNLYKC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.29	0.88
Trophozoite	expressed	0.13	0.94
Schizont	expressed	0.03	0.98
Gametocyte	expressed	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1035800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.143 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8IJ50

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_113672

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	11	6	14
disruptive	30	51	32	60
missense	19	37	24	35

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	23	11	16
disruptive	47	97	51	97
missense	28	71	27	52

PlasmoDB Total SNPs: 249

Non-coding: 40 | Synonymous: 136 | Nonsynonymous: 73 | Stop Codon: 0

Protein Information

Protein Length: 712 | Molecular Weight (kDa): 82.071

UniProt ID(s): Q8IJ50

PDB ID(s): None

Isoelectric Point: 4.05

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104